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Binding Information Page

Drug(oseltamivir carboxylate vegaZZ) and Protein(Sialidase-2, 1VCU)

Affinity Score: -55.171425
Z-score: -1.713003
Z'-score: -2.020532 <= -0.5
Adverse Drug Reaction:neuropsychiatric disorders

Show population with putative diversity in binding strength of this drug-SADR target interaction

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Amino acids within 6.4Å of the drug molecule

PositionAmino acid
21ARG
22ILE
39GLU
41ARG
46ASP
49ALA
83ARG
85MET
86ASN
103ILE
105ILE
111GLU
112GLN
114GLN
115LEU
122THR
156THR
157PHE
158ALA
159VAL
160GLY
161PRO
179TYR
181TYR
189ARG
192PRO
217LEU
218GLU
237ARG
239HIS
269PRO
270GLN
271GLY
272CYS
273GLN
304ARG
333ALA
334TYR
355GLU
359TYR

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SNP information of the residues within 6.4Å of drug molecule

NumResidue PositionResidueRS IDResidue MutantAllelesRefSNP AllelesFunction
141ARGrs2233385(refSNP)R->QN/AA/G[Natural variant] Reduced activity; increased sensitivity to inhibition by oseltamivir carboxylate;